Beijing Children’s Hospital, Capital Medical University
National Center for Children’s Health
Beijing, China
Dr. Wei Li is a professor and vice president of Beijing Children’s Hospital, Capital Medical University. He has been involved in the identification of causative genes for Hermansky-Pudlak syndrome (HPS) and Albinism. His research lab is working on the mechanisms of how HPS protein associated complexes (HPACs) regulate the biogenesis of lysosome-related organelles (LROs), to elucidate the pathogenesis of HPS in which multiple LRO defects exist. Currently, the LROs that his lab is mostly focused on are melanosomes in melanocytes, platelet dense granules (DGs), Weibel-Palade bodies (WPBs) in vascular endothelial cells, lamellar bodies (LBs) in alveolar type II epithelial cells, and large dense core vesicles (LDCVs) in exo/endocrine cells. His clinical lab is dedicated to molecular diagnosis of pediatric patients with inherited disorders by utilizing multi-omics techniques and providing individualized functional assays of disease genes.